Lead Sponsor

Regeneron Pharmaceuticals

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Confirmed diagnosis of solid tumor malignancy
•2. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
•3. Adequate hepatic, renal and bone marrow function
•4. Resolution of toxicity from prior therapy (except alopecia) to grade less than or equal to 1

•1. Patients with brain metastases, spinal cord compression, carcinomatous meningitis, or other evidence of central nervous system involvement
•2. Either systolic BP greater than 140 mm Hg or diastolic BP greater than 90 mm Hg
•3. Patients with medical history of myocardial infarction, unstable angina pectoris, coronary/ peripheral artery bypass graft, congestive heart failure or ventricular arrhythmia
•4. Patients with deep vein thrombosis or pulmonary embolism within last 3 months
•5. Patients with serious non healing wound or acute ulcer
•6. Patients with treatment resistant or bleeding peptic ulcer disease, erosive esophagitis or gastritis, grade 3 or gastrointestinal bleeding/hemorrhage, infectious or inflammatory bowel disease, diverticulitis, or other uncontrolled thromboembolic event within last 3 months
•7. Patients with history of abdominal or tracheal-esophageal fistula
•8. Prior treatment with aflibercept (ziv-aflibercept), Ang2 or Tie2 inhibitors
•9. Prior treatment with bevacizumab within last 6 weeks
•10. Pregnant or breast-feeding women