Sofosbuvir and Ribavirin in Patients With Chronic HCV With Cirrhosis and Portal Hypertension With or Without Liver Decompensation

Exclusion Criteria

• •Have any serious or active medical or psychiatric illness which, in the opinion of the investigator, would interfere with subject treatment, assessment, or compliance
• •HIV or chronic hepatitis B virus (HBV) infection (HBsAg positive)
• •Alpha-fetoprotein (AFP) \> 50 unless negative imaging for hepatic masses within the last 6 months or during screening
• •Refractory ascites as defined by requiring paracentesis \> twice within 1 month prior to screening
• •Active variceal bleeding within 6 months of screening
• •Expected survival of \< 1 year
• •History of hepatorenal, or hepatopulmonary syndrome.
• •Evidence of renal impairment (CrCl \< 50 mL/min)
• •History of major organ transplantation, including liver transplant.