Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
UNC Lineberger Comprehensive Cancer Center
This is a multi-institutional pilot clinical trial designed to estimate the response rate and safety of metformin for the treatment of simple and complex endometrial hyperplasia (EH) without atypia. Enrollment of patients will occur at UNC-Chapel Hill and Southern Pines Women's Health Center. Fifteen patients will be enrolled over the course of 1 year. Metformin will be initiated at 850 mg orally once daily, and titrated up to twice daily over a minimum of 1 months time. Treatment will last 12 weeks and then patients will undergo repeat endometrial biopsy to assess for regression or persistence of EH.
Age
18–75
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Be between the ages of 18-75 years old
Have a confirmed diagnosis of endometrial hyperplasia without atypia based upon endometrial biopsy
Have no contraindications to short-term metformin therapy
Have a creatinine clearance of ≥ 90 ml/min, as calculated by the Cockroft-Gault formula
Have normal serum transaminase values (AST and ALT)
Need to be able to undergo metformin treatment for a duration of 12 weeks prior to repeat endometrial biopsy
You may not be if
Are currently taking metformin or have taken metformin in the past 6 months or have a history of an allergic reaction or intolerance at any time to metformin
Have a history of liver or renal dysfunction.
Have a random glucose of ≤ 65 or ≥ 200
Have a recent history of alcoholism. Former alcoholics who have abstained from alcohol for 5 years or more may be enrolled in this study.
Have a history of vitamin B12 deficiency
Are pregnant
Are currently taking insulin
Are taking a drug that may significantly interact or influence the metabolism of metformin
In the opinion of the investigator, the patient is felt not to be appropriate for the study
