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COMPLETEDPhase 2NCT01683396

Safety and Biologic Activity Study of Gevokizumab to Treat Erosive Osteoarthritis of the Hand

The purpose of this proof-of-concept study is to determine whether gevokizumab is effective in the treatment of active inflammatory, erosive osteoarthritis of the hand.

Lead sponsor: XOMA (US) LLC•27 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

XOMA (US) LLC

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Diagnosis of hand osteoarthritis
•Joint tenderness and/or redness
•At least one erosion by X-ray (as determined by the central reader)
•Contraceptive measures adequate to prevent pregnancy during the study

Exclusion Criteria

•History of inflammatory disease other than hand EOA including: secondary post-traumatic OA; rheumatoid arthritis; spondylarthropathies; erosion of the ulnar styloid process; psoriatic arthritis; skin psoriasis; erosions of the wrist; fibromyalgia
•History of gout, pseudogout, or hemochromatosis
•History of allergic or anaphylactic reactions to monoclonal antibodies
•History of recurrent or chronic systemic infections
•Known allergy to acetaminophen
•Female subjects who are pregnant, planning to become pregnant, have recently delivered, or are breast-feeding

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 4, 2014Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE2

Enrollment87

Start dateJul 2012

Last updatedMar 4, 2014

Condition

Locations shown

Huntsville, Alabama

Tucson, Arizona

Little Rock, Arkansas

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 4, 2014Data synced to Clareo: May 3, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions