An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered Via Transendocardial Catheter-based Injections to Subjects With Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM)

Disease-specific:

1. Severe primary valvular heart disease including, but not limited to, aortic valve stenosis and insufficiency;

2. VAD implantation, heart transplantation, cardiomyoplasty, left ventricular reduction surgery, or cardiac shunt implantation;

3. Planned heart failure-related device interventions (e.g., VAD implantation, initial cardiac resynchronization therapy) or planned cardiac procedures (e.g., heart transplant, cardiomyoplasty, valvular repair);

4. Current arrhythmias that would prohibit accurate NOGA® electromechanical mapping and NOGA®-guided injections;

5. LV thrombus (as documented on echocardiography or LV angiography);

6. Myocardial infarction, stroke or transient ischemic attack within 3 months prior to screening;

7. Percutaneous coronary intervention, valvuloplasty, cardiac surgery, and other major cardiac procedure within 30 days prior to screening;

8. In the opinion of the Investigator, the subject's left ventricular wall is unsuitable for transendocardial injections (due to thickness or other reasons).

Medical History:

9. Stroke or transient ischemic attack (TIA) within 3 months of screening;

10. Hemoglobin A1c (HbA1c) ≥ 9% at screening;

11. Diabetic subjects with uncontrolled or untreated proliferative retinopathy as determined by dilated eye exam administered by a qualified eye care professional as per American Diabetes Association guidelines;

12. Blood clotting disorder not caused by medication (e.g., thrombophilia);

13. Active malignancy (non-basal cell) requiring surgery, chemotherapy, and/or radiation in the past 12 months;

14. Drug or alcohol abuse that would interfere with the subject's compliance with study procedures;

15. Allergies to any equine, porcine, or bovine products;

16. Body mass index (BMI) ≥ 40 kg/m2 at screening;

17. Established chronic kidney disease (CKD) requiring dialysis (Stage 5); estimated creatinine clearance \< 15 mL/min at screening;

18. Subject has allergy or is unable to tolerate cardiac imaging contrast agents; also the inability to get a good quality echocardiogram image at screening (as determined by the imaging core lab).

Laboratory Parameters:

19. Abnormal laboratory values (performed at central lab) at screening:

* Platelets \< 50,000 μL;

* Hemoglobin \< 9.0 g/dL;

* Aspartate aminotransferase/alanine aminotransferase (AST/ALT) \> 3 times the upper limit of normal (ULN);

* Human immunodeficiency virus 1 (HIV 1), HIV 2, or syphilis positive (rapid plasma reagin \[RPR\]);

* Active hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibodies;

* NOTE: Additional lab tests may be performed per local requirements including but not limited to: hepatitis B core antibody, human T lymphotropic virus I/II.

Exclusionary Procedures, Devices, or Medication:

20. Subjects receiving anti-angiogenic drugs (e.g., anti-vascular endothelial growth factor \[VEGF\]);

21. Chronic exposure to cytotoxic therapy for oncologic or chronic non-oncologic reasons in the prior 3 months or expected requirement over the course of the study;

22. Concurrent participation in another interventional clinical trial or receiving experimental intervention within 30 days of screening or having previously been exposed to Aastrom's ixmyelocel T product or previously received allogeneic cell therapy, autologous cell therapy cultured with animal proteins.

23. In the opinion of the Investigator, the subject is unsuitable for cellular therapy or has a food/drug allergy, surgical or medical condition, clinically significant psychiatric disorders, poor nutritional status, or lab abnormality requiring further medical evaluation that may interfere with the investigational product, interfere with the study results' interpretation, interfere with the subject's ability to complete the study or compromise the subject's safety.

What this study is about