Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
With
University of California, San Francisco
National Multiple Sclerosis Society
Age
18–60
Sex
FEMALE
Healthy volunteers
Accepted
You may be eligible if
Female
Healthy or multiple sclerosis
Aged 18 to 60
Body mass index is between 18 kg/m2 and 30 kg/m2
Screening 25-hydroxyvitamin D level ≤ 75 nmol/L (30 ng/mL)
White race
Non-Hispanic ethnicity
Willing to use birth control during study
Willing to not use tanning bed during study
If subject has multiple sclerosis:
Relapsing-remitting MS, as defined by McDonald 2005 criteria
Screening Expanded Disability Status Scale score ≤ 3.0
Using no medication for MS, or taking Copaxone, (glatiramer acetate), interferons, or natalizumab
You may not be if
Pregnant or nursing
Taking multivitamin \& unwilling to remain off it during study
Taking cod liver oil \& unwilling to remain off it during study
On a fat-restricted diet
History of renal disease or nephrolithiasis (kidney stones)
History of liver disease
Taking thiazide diuretics
History of hyperthyroidism
History of infection with Mycobacterium species
History of sarcoidosis
History of cancer
History of cardiac disease
History of HIV
History of gastrointestinal disorder
Taking medications that interfere with gastrointestinal absorption
Cigarette smoker in past month
Use of illicit drugs in past month
Use of steroids in past month
History of hypercalcemia, and screening serum calcium ≤ 10 mg/dL (UCSF) or ≤ 10.7 mg/dL (Johns Hopkins)
History of hypercalciuria
Evidence of anemia (Hgb \<11.0 g/dL)
History of other serious medical conditions
Taking medications that involve the P450 system or may interact with vitamin D (digoxin, diltiazem, verapamil, cimetidine, heparin, or low-molecular weight heparin)
Other concerns about safety from the perspective of the treating physician
If subject has MS:
History of major heat sensitivity (leading to sun-avoidant behaviors)
Clareo Health | Pharmacokinetics of Vitamin D in Multiple Sclerosis and in Health
