Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
London Health Sciences Centre
Age
18–59
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
\- Males/Females who are ≥ 18 years old and ≤ 59 years old
Relapsing Remitting, Secondary Progressive or Primary Progressive MS, as per revised McDonald's Criteria
Have not received corticosteroids in last thirty days or a relapse in the last ninety days
An Expanded Disability Status Scale (EDSS) of ≤ 6.5
If female, must neither be pregnant nor breast-feeding
You may not be if
\- Have evidence of other medical cause(s) of cognitive impairment
Have evidence of major depression as determined by a positive Beck Depression Index-Fast screen ≥ 13and/or by clinician interview or evidence of severe fatigue with a Fatigue Severity Scale ≥ 5.
Have demonstrated a hypersensitivity to amphetamines in the past
Have uncontrolled or labile hypertension (\> 135/85 mm Hg, treated or untreated)
Have a history of structural heart disease, including atherosclerosis or angina
Have a diagnosis of bipolar disorder or a history of a psychotic episode
The following medications are not permitted to be used within 14 days the study
1. Monoamine Oxidase Inhibitors
2. Sympathomimetics or methadone
3. Antipsychotic agents
4. Modafinil
The following medications are permitted if the dose has been stable for ≥ 28 days
1. Short acting benzodiazepines, qhs administration only
2. Anticonvulsants, including gabapentin and pregabalin
