The Use of Ketorolac in Surgical Neonates

Exclusion Criteria

• •1. Gestational age \< 37 weeks
• •2. Age less than one week or greater than 3 months of age
• •3. Known renal disease/dysplastic kidneys
• •4. Serum Creatinine \> 0.4
• •5. Patients who have rising creatinine levels the day prior to surgery (increase of at least 1.5-fold from baseline)
• •6. Patients who are currently receiving other potentially renal toxic drugs or drugs that may interfere with hemostatic pathways as part of their clinical care (including but not limited to furosemide, hydrochlorothiazide, vancomycin, gentamicin, aspirin, tpa \[except for use of thrombosed central venous catheters\], enalapril, systemic heparin \[except for use in central venous catheter flushes\])
• •7. Patients who undergo nephrectomy
• •8. Patients with necrotizing enterocolitis
• •9. Patients with a hemoglobin value \< 10g/dL
• •10. Recent (within 3 months) GI bleeding, ulceration, and/or perforation
• •11. Platelet count \< 50,000
• •12. Ongoing disseminated intravascular coagulation or history of intraventricular hemorrhage
• •13. Recent (within 2 weeks) use or current use of other nonsteroidal anti-inflammatory drugs (NSAIDS) besides aspirin (ASA)
• •14. Allergy to ASA or other NSAIDS