Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
GlaxoSmithKline
Age
30–55
Sex
MALE
Healthy volunteers
Accepted
You may be eligible if
Healthy male subjects between 30 and 55 years of age, with body weight between 60 to 80 kilograms (kg) and a history of regular bowel movements
Male subjects with female partners of child-bearing potential must agree to use one of the contraception methods from first dose of study medication until the final follow up visit
Alanine aminotransferase (ALT), alkaline phosphatase and bilirubin =\<1.5x upper limit of normal
QT interval by Bazett's correction formula (QTcB) \<450 millisecond (msec); or QTcB \<480 msec in subjects with Bundle Branch Block
Available to complete the study and return for follow-up visits if necessary
Capable of giving written informed consent
You may not be if
Any condition that could interfere with the accurate assessment and recovery of radioactivity \[14C\]
Participation in a clinical trial involving administration of radiolabeled 14C-labelled compound(s) within the last 12 months
Any condition which impairs the absorption, distribution, metabolism or excretion of the investigational product
Subjects with a history of cholecystectomy
Subject has received a total body radiation dose of greater than 5.0 millisievert (mSv) or exposure to significant radiation during 1 year before dosing
The subject has a positive: drug/alcohol, Hepatitis, HIV screen
Abuse of alcohol
History of liver disease, or known hepatic or biliary abnormalities
The subject has recently received an investigational product
Donation of more than 500 mL blood within a 56 day period
Unwillingness or inability to follow the procedures outlined in the protocol
Use of prescription or non-prescription drugs
Subject is mentally or legally incapacitated
History of sensitivity to heparin or heparin-induced thrombocytopenia
Smoking or history or regular use of tobacco or nicotine-containing products
Unable to refrain from consumption of red wine, Seville oranges, grapefruit or grapefruit juice from 7 days prior to the first dose
