Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
Age
50–80
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Post-menopausal women aged 50-80 years
T score \< -2.5 at lumbar spine, total hip or femoral neck on dual x-ray absorptiometry (DXA) OR T score \< -1.5 with a personal or family history of fracture
You may not be if
Previous use of bisphosphonates or Teriparatide; current estrogen therapy; any other osteoporosis therapy in the past 6 months
Metabolic bone disease other than osteoporosis
Body mass index (BMI) \< 18
Weight \> 325 lbs
Current smoking or current alcohol use that exceeds 3 units of alcohol daily
Use of medications known to affect bone metabolism
Renal disease, history of kidney stones or hypercalciuria
Hypo- or hyperparathyroidism; hypo- or hypercalcemia
Serum vitamin D level \< 20 ng/dL
Refusal to adjust their dietary calcium to \<750mg (i.e. two servings per day of calcium rich food)
History of bone marrow or organ transplant
History of malignancy or radiation to the bone
History of esophageal stricture, dysmotility or severe reflux disease
Gastrointestinal malabsorption
Use of digoxin
Need for chronic anticoagulation therapy such as Coumadin, heparin or low molecular weight heparin or inability to discontinue anti-platelet medication
Bleeding diathesis; hemoglobin ≤ 12.5 g/dL (American Red Cross cut-off to donate blood)
International normalized ratio (INR) pro time \> 1.1 or activated partial thromboplastin time (APT) T ratio \> 1.2
Platelets \< 150K/cu mm
Cellulitis at site of iliac crest
History of allergy to medications used in bone biopsy (demeclocycline, lidocaine)
Inability to understand and provide informed consent.
Clareo Health | Stem Cell Recruitment in Osteoporosis Therapy
