A Study of LY2605541 Versus Insulin Glargine on Blood Sugar

Exclusion Criteria

• •All Participants
• •Have a hemoglobin level \<12.0 grams/deciliter (g/dL)
• •Are currently a smoker, used tobacco products on a regular basis in the 6 months prior to screening, or are intending to smoke during the study
• •Healthy Participants ONLY
• •Regular use or intended use of over-the counter or prescription medication within 7 and 14 days, respectively, prior to dosing (apart from vitamin/mineral supplements or occasional use of acetaminophen or ibuprofen).
• •Participants with T1DM ONLY
• •Regular use or intended use of any over-the-counter or prescription medications or nutritional supplements that affect blood glucose or the body's sensitivity to insulin or that promote weight loss within 14 days prior to dosing
• •Are receiving chronic (lasting longer than 14 consecutive days) systemic or inhaled glucocorticoid therapy (excluding topical, intra-articular, and intraocular preparations) or have received such therapy within the 4 weeks before dosing
• •Require a total daily insulin dose exceeding 100 units (U)
• •Have fasting triglycerides \>400 mg/dL