Effect of a Goal Setting Intervention on Exercise in Women With Metastatic Breast Cancer: An Exploration of The Lipogenic Pathway

Inclusion Criteria

• •Subjects with measurable per Response Evaluation Criteria in Solid Tumors (RECIST) criteria 1.1 and biopsy-able (as determined by Co-Investigator John Gemery, MD) metastatic carcinoma of the breast.
• •Physically able to undertake a moderate physical activity program.
• •Greater than 4 weeks from any radiation treatments for metastatic disease.
• •standard of care biopsy must occur within 30 days of registration.
• •Able to follow directions and fill out questionnaires and physical activity diaries in English.
• •Willing to consent to biopsies and be randomly assigned to one of two study arms which may or may not include physical activity goal setting.
• •Consents to be contacted via phone or internet (see Appendix K).
• •No to all questions on Physical Activity Readiness Questionnaire (see appendix A) or approved by primary oncologist or other care provider provider for participation.
• •Hb \>10 without transfusion, liver function tests less than 3 times upper limits of normal, normal thyroid-stimulating hormone (TSH), absolute neutrophil count (ANC) \>1500.
• •Karnofsky performance status ≥ 80%
• •Previous Physical Therapy consultation and treatments acceptable.
• •Participation in other trials acceptable.
• •CNS disease that is treated and stable by MRI for at least 6 months