Pramipexole as a Treatment for Cocaine Dependence

Exclusion Criteria

• •Have any history or evidence suggestive of seizure disorder or brain injury.
• •Have any previous medically adverse reaction to cocaine, including loss of consciousness, chest pain, or epileptic seizure.
• •Have neurological or psychiatric disorders, such as: psychosis, bipolar illness or major depression as assessed by SCID; organic brain disease or dementia assessed by clinical interview; history of any psychiatric disorder that would require ongoing treatment or that would make study compliance difficult; and history of suicide attempts within the past year and/or current suicidal ideation/plan.
• •Have evidence of clinically significant heart disease or hypertension, as determined by the PI.
• •Have a family history in first-degree relatives of early cardiovascular morbidity or mortality, as determined by the PI.
• •Have evidence of untreated or unstable medical illness including neuroendocrine, autoimmune, renal, hepatic, or active infectious disease.
• •Have HIV and are currently symptomatic or are taking antiretroviral medication.
• •Be pregnant or nursing. Females must provide negative pregnancy urine tests upon hospital admission and at the end of study participation. Females must either be unable to conceive (i.e., surgically sterilized, sterile, or postmenopausal) or be using a reliable form of contraception (e.g., abstinence, birth control pills, intrauterine device, or condoms with spermicide).
• •Have asthma or currently use theophylline or other sympathomimetics.
• •Have any other illness, condition, or use of psychotropic medications, which in the opinion of the PI and/or the admitting physician would preclude safe and/or successful completion of the study.