A Study of MEK162 and Paclitaxel in Patients With Epithelial Ovarian, Fallopian Tube or Peritoneal Cancer

Exclusion Criteria

• •History or concurrent evidence of retinal vein occlusion (RVO) or current risk factors for RVO.
• •Prior therapy with a MEK inhibitor.
• •History of hypersensitivity to taxanes or drug formulations containing Cremophor®.
• •History of acute coronary syndromes.
• •Uncontrolled or symptomatic brain metastases that are not stable, require steroids, are potentially life-threatening or that have required radiation within 28 days prior to first dose of study treatment.
• •Concomitant malignancies or previous malignancies with less than a 5-year disease-free interval at the time of enrollment; patients with adequately resected basal or squamous cell carcinoma of the skin, carcinoma in situ of the cervix or ductal carcinoma in situ may enroll irrespective of the time of diagnosis.
• •Known positive serology for the human immunodeficiency virus (HIV), active hepatitis C, and/or active hepatitis B.
• •Treatment with ritonavir at the time of first dose of study treatment.
• •Treatment with continuous or intermittent small molecular therapeutics, biologic therapy or hormonal therapy within 28 days prior to first dose of study treatment.
• •Treatment with a cyclical chemotherapy within a period of time that is less than the cycle length used for that treatment prior to first dose of study treatment.
• •Treatment with any other investigational agents within a period of time that is less than the cycle length used for the treatment or within 28 days (whichever is shorter) prior to first dose of study treatment.
• •Treatment with prior radiotherapy within 21 days prior to first dose of study treatment; however, if the radiation portal covered ≤ 10% of the bone marrow reserve, the patient may be enrolled irrespective of the end date of radiotherapy.
• •Additional criteria exist.