Diagnosis of Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma,

Ages \>/= 1 and \</= to 30 years at the time of initial diagnosis

Undergoing asparaginase treatment for ALL or lymphoblastic lymphoma

Documented Grade 2 or higher hypersensitivity reaction to native or pegylated E. coli asparaginase or Calaspargase pegol

Must have two remaining weeks of native E. coli asparaginase treatment or 1 remaining dose of either Pegaspargase or Calaspargase pegol

Direct bilirubin less than or equal to Grade 2

Amylase and lipase within normal limits (per institutional standards)

Signed informed consent by the patient is greater than or equal to 18 years or by the parent if the patient is younger than 18 years old.

A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy