Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sun Yat-sen University
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of hepatocellular carcinoma patients, in accordance with HCC Professional Committee of the Chinese Anti-Cancer Association 2001 "Clinical Diagnosis of Primary Liver Cancer and Staging Criteria"
solitary tumor ≤5cm, or three or fewer lesions none ≤3cm，As Milan criteria
History of hepatitis B or HBsAg positive
Cirrhosis and portal hypertension
No treatment on liver cancer before
KPS score ≥ 70
The age of 18 to 65 years
Child-Pugh A or B (Class B, scoring no more than 7 points)
Baseline laboratory test comply with the following criteria:
* White blood cell ≥ 1.0×109/L
* Platelet ≥ 25×109/L
* Hemoglobin ≥ 80g/L
* Serum ALT,AST ≤ 3×upper limit of normal (ULN)
* Serum creatinine ≤ 1.5 × ULN
* INR\<1.5, or prothrombin time \<ULN +4 sec
* Albumin ≥30g/L
* Total bilirubin ≤34mmol/L
Informed consent with signature and time
Good patient compliance
The surgical group patients received radical hepatectomy. Radical surgery is defined as: complete resection of visible tumor, R0 resection margins, and also including:
* The number of tumors is less than 3
* No tumor thrombus found in major branch of the portal veins, hepatics, inferior vena cava or bile duct
* No hepatic hilar lymph node metastasis
* No extrahepatic metastasis
You may not be if
extrahepatic metastasis; With metastasis in major branch of portal vein, hepatic vein
History of hepatitis C or HCV-Ab positive
Pugh Child-Pugh C, or with massive ascites or had a history of hepatic encephalopathy, or Upper digestive tract bleeding
Poor physical condition or cachexia
During the past 12 months just before the study, there had been any of the following: myocardial infarction, severe/unstable angina, coronary artery bypass graft surgery, congestive heart failure, cerebrovascular accident (including transient ischemic attack), pulmonary embolism; arrhythmia according to the NCI-CTCAE ≥ grade 2, QTc interval extension (male\> 450 ms, female\> 470 ms);
Renal insufficiency, need peritoneal dialysis or hemodialysis
Serious dysfunction of other organs
History of second primary malignant tumors
Known or new evidence of brain or leptomeningeal disease
Hemophilia or bleeding tendency, and are taking therapeutic doses of coumarin derivative anticoagulant therapy drugs
Pregnant or lactation, all female patients with childbearing potential must have a pregnancy test (serum or urine) within 7 days after enrollment,and the result is negative
History of organ transplantation
Known HIV infection
With any other serious acute and chronic physical or mental disease or abnormal laboratory tests, which are likely to increase risks or interfere with the interpretation of the results, or researchers believe that patients are not suitable for enrollment
Clareo Health | Optimal Treatment on Hepatocellular Carcinoma (HCC) With Cirrhotic Portal Hypertension
