Resveratrol and Type 2 Diabetes

Exclusion Criteria

• •Unstable body weight (weight gain or loss \> 3kg in the last three months)
• •Total body fat percentage \< 25%
• •Hemoglobin \< 7.8 mmol/l
• •Use of anticoagulants
• •Engagement in programmed exercise \> 2 hours total per week
• •Impaired kidney and/or hepatic function Creatinine 50-100 umol/L Liver enzymes, within 2 times of normal range of laboratory standard (ASAT \< 60 U/L, ALAT \< 70 U/L, Billi \<40 umol/L, gamma-GT \< 80 U/L)
• •No diabetes related co-morbidities like cardiovascular diseases, diabetic foot, polyneuropathy, retinopathy
• •Insulin dependent Diabetic subjects
• •Any medical condition except type 2 diabetes mellitus requiring treatment and/or medication use except metformin only or in combination with sulfonylurea agents
• •Intake of dietary supplements except multivitamins and minerals
• •Current alcohol consumption \> 20 grams/day
• •Subjects who don't want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study.
• •Participation in another biomedical study within 1 month before the first screening visit
• •Any contraindication to MRI scanning. These contra-indications include patients with following devices:
• •* Central nervous system aneurysm clip
• •* Implanted neural stimulator
• •* Implanted cardiac pacemaker of defibrillator
• •* Cochlear implant
• •* Insulin pump
• •* Or metal containing corpora aliena in the eye or brains