The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms

Exclusion Criteria

• •Females who are pregnant or intend to become pregnant during the study. (Females of child-bearing potential must have a urinary pregnancy test within 7 days of enrollment)
• •Extradural aneurysms
• •Known multiple untreated cerebral aneurysms at study entry
• •Recent history of subarachnoid hemorrhage, intracranial hemorrhage, or major surgery within one month of enrollment
• •Admission platelet \<50,000 or any known hemorrhagic diathesis, coagulation deficiency, or on oral anticoagulant therapy with an INR \>3.0
• •Contraindication to angiography such as elevated creatinine or known allergy to angiographic contrast
• •Contraindication to CT and/or MRI scans
• •Known allergy to the metal component of the Penumbra Liberty Stent System
• •Evidence of active infection (WBC \>10x109 /L)
• •Any medical conditions that will not allow the necessary follow-up for this study (e.g., pre-existing neurological or psychiatric diseases)
• •Current substance-abuse /illicit drug use
• •Angiographic evidence of an arterial stenosis proximal to the target lesion that could prevent device deployment
• •Contraindications to study medications (heparin, aspirin, clopidogrel, and radiographic contrasts)