Lead Sponsor

Centre Leon Berard

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•patient with a NSCLC, non-resected, non-metastatic including a parenchyma portion
•Age \>= 18 years
•PS \<=2
•CT-scan within 3 months at inclusion
•PET-scan within 3 months at inclusion
•Respiratory functional exploration within 3 months at inclusion
•estimated V20 (by radiotherapist)\< 35% on conventional pre-radiotherapy imaging
•Tumor T0 to T4, M0; N1, N2 ou N3 by isolateral supra-clavicular involvement
•Measurable disease according to RECIST criteria 1.1
•Curative intent Chest conventional radiation therapy
•Radiation indication validated by a multidisciplinary meeting
•Adequate contraceptive method for the whole study duration and for up to 28 days after the end of radiation
•Mandatory affiliation with a health insurance company
•Patients must provide dated \& written consent

•Prior surgery for NSCLC
•NSCLC nearby pulmonary apex or strictly intra-thoracic with no intra-parenchyma portion
•Metastatic disease or N3 contralateral lymph node
•History of chest irradiation
•History of known increased intrinsic radiosensibility
•Hypersensibility to active substance or excipient of fluoro-deoxyglucose-18F
•Life expectancy \< 6 months
•Patient with a concurrent malignancy or with a history of malignancy (excepted adequately treated basal cell skin carcinoma or cervical squamous cell carcinoma or other malignancies free of the disease for at least 5 years)
•Pregnant or breastfeeding women
•Psychological, sociological or geographical conditions that would limit compliance with study requirements
•Patient deprived of freedom
•Patient has concomitant participation to an other investigational study

Related studies

NCT06043817 · Non-Small Cell Lung Cancer, NSCLC, and more

NCT07144280 · Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic, and more

NCT06758401 · Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, and more

NCT07540260 · Radiation Therapy, Metastatic Renal Cancer, and more

NCT07431827 · Non-small Cell Lung Cancer

Phase 2 Study Evaluating Mid-position Strategy in Radiotherapy Treatment for Patients With a Locally Advanced Non-small Cell Lung Carcinoma