A Study of Onartuzumab (MetMAb) in Combination With Bevacizumab Compared to Bevacizumab Alone or Onartuzumab Monotherapy in Participants With Recurrent Glioblastoma

Inclusion Criteria

• •Histologically confirmed glioblastoma at first recurrence after concurrent or adjuvant chemoradiotherapy
• •Imaging confirmation of first tumor progression or regrowth as defined by RANO criteria
• •Prior treatment with temozolomide
• •No more than one prior line of chemotherapy
• •No prior treatment with bevacizumab or other vascular endothelial growth factor (VEGF)- or VEGF-receptor-targeted agent
• •No prior exposure to experimental treatment targeting either hepatocyte growth factor (HGF) or Met pathway
• •No prior treatment with prolifeprospan 20 with carmustine wafer
• •No prior intracerebral agent
• •Recovery from the toxic effects of prior therapy
• •No evidence of recent hemorrhage on baseline magnetic resonance imaging (MRI) of the brain
• •No need for urgent palliative intervention for primary disease (e.g. impending herniation)
• •Karnofsky performance status greater than or equal to (\>=) 70 percent (%)
• •Stable or decreasing dose of corticosteroids within 5 days prior to randomization
• •Prior therapy with gamma knife or other focal high-dose radiotherapy is allowed, but the participant must have subsequent histologic documentation of recurrence, unless the recurrence is a new lesion outside the irradiated field
• •Participants who have undergone recent surgery for recurrent or progressive tumor are eligible provided that: surgery must have confirmed the recurrence, a minimum of 28 days must have elapsed from the day of surgery to randomization and for core or needle biopsy, a minimum of 7 days must have elapsed prior to randomization, and craniotomy or intracranial biopsy site must be adequately healed and free of drainage or cellulitis, and the underlying cranioplasty must appear intact at the time of randomization
• •Availability of formalin fixed paraffin embedded tumor tissue representative of glioblastoma