Clareo Health | A Comparison of microRNA Samples in Patients With Nasal Polyps and Aspirin Exacerbated Respiratory Disease and Those With Nasal Polyps Only
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of South Florida
Nasal epithelial tissue will be collected from the inferior nasal turbinates of ten subjects with nasal polyps and AERD disease and from the inferior turbinates of ten subjects with nasal polyps but without AERD. A rhinoprobe™ will be used to collect this epithelial tissue. These samples will be analyzed by miRNA assay to determine if there is a difference in mircroRNA expression between the two subject groups.
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Ages eligible for study: 18 to 70 years
Genders eligible for study: male and female
Signed and dated written informed consent is obtained prior to study
Subjects have a physician diagnosis of nasal polyps without AERD or physician diagnosis of nasal polyps with AERD. The diagnosis of aspirin sensitive asthma must be present for a minimum of three months. If the medical history is indeterminate either an aspirin challenge will be required to confirm or rule out the diagnosis. An aspirin challenge is a protocol that can safely be performed as an out patient procedure with close supervision.
You may not be if
Pregnant and/or lactating females.
Current tobacco use.
Severe psychiatric illness.
Current illicit substance use or dependence and/or abuse of alcohol.
Primary or secondary immunodeficiency.
Any clinically significant uncontrolled medical condition that would put the patient at risk.
