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Keep this study
Lead
Murdoch Childrens Research Institute
With
Austin Health
Royal Brisbane and Women's Hospital
Fremantle Hospital and Health Service
Melbourne Health
The University of Queensland
There is mounting evidence that treatment of moderate iron overload in HFE related hereditary haemochromatosis (HH) is not necessary. This project aims to undertake a randomised patient-blinded trial of erythrocytapheresis compared to sham erythrocytapheresis (using plasmapheresis) in individuals who have serum ferritin (SF) above the upper limit of the normal range but \< 1000ug/L (defined here as moderate iron overload) due to HFE mutations and to compare the prevalence of symptoms and objective markers of disease in the two treatment arms.
Age
18–70
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
1. HFE C282Y homozygous.
2. Aged 18 - 70 years .
3. SF above the upper limit of the normal range of 300µg/L but less than 1000µg/L with a currently or previously raised TS (\>greater than the upper limit of normal for the testing laboratory).
You may not be if
1. HH due to genotypes other than HFE C282Y homozygosity.
2. Normal SF, SF \> 1000µg/L.
3. Other major risk factor(s) for liver toxicity or other significant co-morbidities including positivity for hepatitis B or C, excess alcohol consumption (\> 60g/day in males and 40g/day in females) or body mass index \> 35.
4. Has had venesection therapy for HH in the last two years.
Clareo Health | Mi-iron - Moderately Increased Iron - is Reducing Iron Overload Necessary?
