Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Hospital, Bordeaux
Age
60–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
All patient groups:
Age \>60 years
Normal vision work-up : (corrected binocular visual acuity \> 8/10)
Written informed consent
Subjects affiliated to Social Security
Group A: Prodromal AD.
Memory complaints.
Normal or slight restriction of IADL.
"hippocampal-type" amnesic syndrome defined by poor free recall despite adequate (and controlled) encoding, decreased total recall because of insufficient effect of cuing or impaired recognition, numerous intrusions (RL/RI-16items)
CDR (Clinical Dementia Rating Scale) ≥ 0,5
Persistence of memory changes at a subsequent assessment (\>3 months)
Absence of global cognitive deterioration (MMSE ≥24)
Exclusion of other disorders that may cause mild cognitive impairment with adequate tests
1.5 Tesla diagnosis MRI with at least T2, Flair transversal sections and coronal T1 sections in the coronal plan. Absent or slight medio temporal/hippocampal atrophy or if available (non mandatory) characteristic CSF betaA42/tau ratio
Group B: Typical AD (mild to moderate)
NINDS-ADRDA diagnosis criteria
MMSE ≥ 20
Group C: Control subjects
No memory or other significant cognitive complain.
MMSE ≥ 24
You may not be if
All groups :
Clinically significant vision abnormality(P8 without glasses)
Oculomotor deficit or strabismus
Depression (GDS) with treatment
Subjects unable to give their informed consent
Controls :
Memory or any other significant cognitive complain.
Abnormalities at inclusion (V0) neuropsychology testing suggestive of a cognitive deficit.
