Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Eisai Inc.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with localization-related epilepsy, who have added a second drug to the monotherapy, haven't obtained an adequate reduction of seizure frequency with this combination and have responded to zonisamide added as third drug for at least three months.
Age ≥ 18 years;
Patients with non progressive localization-related epilepsy;
Patients who are able and willing to give written Informed Consent;
Current treatment with three antiepileptic drugs. The last antiepileptic drug introduced must be zonisamide;
50% or greater seizure reduction\* as assessed after an at least three-month maintenance period with zonisamide.
* = seizure frequency before starting zonisamide must be documented checking case histories.
You may not be if
Patients contraindicated for zonisamide use (see SmPC);
Patients with renal or hepatic impairment;
Pregnant or lactating women;
Women of childbearing age who are not willing to use any contraceptive method with established efficacy.
Patients suffering from clinically significant psychiatric illness, psychological or behavioral problems which could interfere with study participation;
Patients with a history (within the last 12 months) of alcohol or drug abuse or dependency;
Patients who have been on an investigational drug or device within 30 days prior to the initiation of the present study;
Patients with a documented computed axial tomography (CAT) scan or magnetic resonance imaging (MRI) scan confirming the presence of a progressive neurological lesion within 12 months of the screening visit.
