Sponsors

Lead Sponsor

Children's Oncology Group

Collaborators

National Cancer Institute (NCI)

OBJECTIVES: I. To identify global changes in the epigenome and various underlying histone modifications that characterize relapsed acute lymphoblastic leukemia (ALL). II. To identify specific transcription factor-binding sites associated with histone alterations. III. To correlate gene expression changes of differentially regulated genes at relapse with underlying chromatin modifications. OUTLINE: Archived bone marrow samples, collected at the time of diagnosis and relapse, are analyzed for gene expression and histone modifications by microarray, chromatin immunoprecipitation (ChIP) sequencing, and quantitative real-time polymerase chain reaction (qRT-PCR).

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Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia

What this study is about

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Sponsors

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