Everolimus and Anakinra or Denosumab in Treating Participants With Relapsed or Refractory Advanced Cancers

Inclusion Criteria

• •Patients with advanced or metastatic cancers that are refractory to standard therapy, relapsed after standard therapy, or who have no standard therapy available that improves survival by at least three months.
• •Patients must be \>= 3 weeks beyond treatment with a cytotoxic chemotherapy regimen, or therapeutic radiation, or major surgery. Patients may have received palliative localized radiation immediately before or during treatment provided that radiation is not delivered to the only site of disease being treated under this protocol. For biologic/targeted agents patients must be \>= 5 half-lives or \>= 3 weeks form the last dose (whichever comes first).
• •Eastern Cooperative Oncology Group (ECOG) performance status =\< 2.
• •Absolute neutrophil count (ANC) \>= 1,000/mL.
• •Platelets \>= 75,000/mL.
• •Creatinine clearance \>= 35 ml/min.
• •Total bilirubin =\< 2 X upper limit of normal (ULN) (exceptions may apply to benign non-malignant indirect hyperbilirubinemia such as Gilbert syndrome). Exception for patients with liver metastasis: total bilirubin =\< 3 x ULN.
• •Alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) and or aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]) =\< 5 X ULN. Exception for patients with liver metastasis: ALT (SGPT) =\< 8 X ULN.
• •Fasting lipid profile: cholesterol =\< 350 mg/dL.
• •Fasting lipid profile: triglycerides =\< 400 mg/dL.
• •Corrected calcium \>= 8.4 mg/dL.
• •Phosphorus \>= 2.5 mg/dL for denosumab.
• •Oral examination and appropriate preventive dentistry will be performed prior to the initiation of denosumab therapy.
• •Negative tuberculosis quantiferon test for anakinra arm.
• •Negative serology for histoplasma, blastomycosis, and Coccidioidomycosis for anakinra arm.
• •Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 30 days after the last dose.
• •Patients must be able to understand and be willing to sign a written informed consent document.