Statins and Selective Cyclooxygenase-2 Receptor Inhibitors in Blunt Chest Trauma

Exclusion Criteria

• •Penetrating trauma
• •Current use of lipid-lowering therapy, use of non steroidal anti-inflammatory drugs.
• •Current use of postmenopausal hormone-replacement therapy
• •Evidence of hepatic dysfunction (an alanine aminotransferase level more than twice the upper limit of the normal range), a creatine kinase level more than three times the upper limit of the normal range.
• •Creatinine level higher than 2.0 mg/dl
• •Known uncontrolled hypertension (systolic blood pressure \>190 mm Hg or diastolic blood pressure \>100 mm Hg
• •History of uncontrolled hypothyroidism (thyroid-stimulating hormone level\> 1.5 times the upper limit of the normal range)
• •Psychiatric disorders
• •Pregnancy
• •Known allergy or intolerance to one of the protocol drug