Manifest secondary tumor

Organ metastases on CT-scan /MRI or in Histology

Myocardial infarction or stroke within the last 6 months

Severe cardiovascular (Grade III - IV according to NYHA), pulmonary (pO2 \< 60 mmHg), renal, hepatic oder hematopoetic impairment

Severe active or chronic infection (z.B. pos. HIV-Antibody-Test, HBs-Ag-detected in Serum and/ or chronic Hepatitis)

Severe psychiatric disease

Previous chemotherapy

Previous pelvine radiotherapy

Detection of Micrometastases in Lymph Nodes of Patients With Prostate Cancer