Metastatic or advanced solid tumor, that has recurred or progressed following standard therapies, or for which no standard therapy exists
Must have available tumor tissue or be willing to undergo biopsy prior to enrollment
Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1
Blood Chemistry and Hematology results within defined limits
You may not be if
History of severe allergic or anaphylactic reactions or hypersensitivity to recombinant proteins or excipients in the investigational agent
Current central nervous system (CNS) or leptomeningeal metastases, or history of CNS or leptomeningeal metastases.
Significant conduction disturbance, history of a severe arrhythmia, or history of a familial arrhythmia
Significant cardiovascular disease
Significant thromboembolic or vascular disorders within prior 3 months
Any other medical condition or psychiatric condition that, in the opinion of the Investigator, might interfere with the subject's participation in the trial or interfere with the interpretation of trial results
Known history of positive results for hepatitis C, hepatitis B, or human immunodeficiency virus.
