Pharmacokinetics, Pharmacodynamics and Cervicovaginal Lavage of Combined Oral Contraceptives and Raltegravir

Inclusion Criteria

• •Women between 20-40 years of age with regular monthly menses
• •If over age 35 then must not use tobacco
• •Negative pregnancy test
• •No known allergy to raltegravir
• •No known history of phenylketonuria
• •Undetectable HIV viral load
• •No active liver disease as determined by medical history and normal AST and ALT
• •No history of hepatic adenomas, carcinomas or benign liver tumors
• •Ho history of thrombophlebitis of thromboembolic disease
• •No history of deep vein thrombosis
• •No history of cerebral vascular or coronary artery disease
• •No known or suspected carcinoma of the breast
• •No undiagnosed abnormal genital bleeding
• •Not taking concomitant CYP 450 inducing medications such as anti-seizure medications
• •No use of oral contraceptives, depot-medroxyprogesterone acetate, contraceptive ring or patch within two months of screening
• •No cholestatic jaundice of pregnancy or jaundice with prior contraceptive pill use
• •Has used raltegravir prior to screening
• •Has no history of malignancy of the genital tract (e.g. cervical cancer, ovarian cancer, endometrial cancer)
• •Must not have had an abnormal pap test defined without resolution in the last 18 months.