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Effect of Omega-3 Fatty Acid on Vitamin D Activation | Clinical Trials | Clareo Health

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Effect of Omega-3 Fatty Acid on Vitamin D Activation

Effect of Omega-3 Fatty Acid on Vitamin D Activation in Hemodialysis Patients

NCT01596842•Dong-A University

Summary

Extra-renal sources of 1, 25-dihydroxyvitamin D can be increased to normal serum 1, 25-dihydroxyvitamin D levels in chronic kidney disease patients after administration of high dose 25-hydroxyvitamin D. The investigators observed that 1, 25-dihydroxyvitamin D concentrations were significantly increased after 3 months of omega-3 FA supplementation compared to baseline levels without 25-hydroxyvitamin D administration in dialysis patients. In this study, the investigators hypothesized that omega-3 FA and 25-hydroxyvitamin D supplementations may increase 1, 25-dihydroxyvitamin D concentrations much more compared to 25-hydroxyvitamin D supplementation only in hemodialysis patients with insufficient or deficient 25-hydroxyvitamin D levels.

Eligibility

Age

20 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients who were treated with hemodialysis for at least 6 months with 25-hydroxyvitamin D \< 30 ng/mL

Exclusion Criteria

•Patients with a history of active infection within 3 months,
•Patients with fish oil or omega-3 fatty acid supplementation within 3 months,
•Patients with a history of fish, gelatin, and/or omega-3 fatty acid allergies,
•Patients with a history of hospital admission within 3 months,
•Patients with a history of bleeding within 3 months,
•Patients with thrombocytopenia,
•Patients with current use of warfarin,
•Patients with an albumin level \< 3.0 g/dL,
•Patients with malignancy and/or liver cirrhosis

Locations (1)

Won Suk An

Busan, South Korea

Key Dates

Start Date

May 1, 2012

Primary Completion Date

December 1, 2012

Completion Date

December 1, 2012

Last Updated

March 10, 2015

Enrollment

ACTUAL participants

Conditions

Hemodialysis PatientsVitamin D InsufficiencyVitamin D Deficiency

Interventions

Omega-3 fatty acid ethylester 90

DRUG

Olive oil

OTHER

cholecalciferol

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 10, 2015Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Effect of Omega-3 Fatty Acid on Vitamin D Activation

Inclusion Criteria

Exclusion Criteria

The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients

Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients

Randomized Trial of Enteral Vitamin D Supplementation in Infants < 28 Weeks Gestational Age or <1000 Grams Birth Weight

Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.

Isolation of Vitamin D Binding Protein Isoforms From Human Volunteers

The Effect of Education Given to Hemodialysis Patients With Pecha Kuka Method on Attitude Towards Diet Therapy and Compliance With Fluid Restriction