Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)

Primary Objectives The primary objectives of this trial are to: 1. Determine the efficacy of an aggressive treatment protocol in eradicating persistent MRSA infection in individuals with CF. 2. Determine the safety of an aggressive treatment protocol in eradicating persistent MRSA infection in individuals with CF. Secondary Objectives The secondary objectives of this trial are to: 1. Determine the efficacy of an aggressive treatment protocol in improving Forced Expiratory Volume (FEV)1, time to exacerbation, and quality of life in individuals with CF and persistent MRSA infection. 2. Determine if there is benefit to adding nebulized vancomycin to an aggressive oral antibiotic treatment protocol in eradicating persistent MRSA infection in individuals with CF.