Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Guilan University of Medical Sciences
Atypical antipsychotics including olanzapine are associated with significant metabolic side effects. Animal studies have suggested that melatonin might prevent some of the olanzapine-associated side effects. Melatonin is safe and is widely used as a sleep-promoting complement, and is not associated with side effects seen with other used drugs such as metformin.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18-65 year
First episode schizophrenia (DSM-IV-TR)
Ability to take medicine orally
Eligible for starting olanzapine
You may not be if
Married women who are at reproductive age
History of taking olanzapine in the recent 3 months
History of allergy or intolerance to olanzapine
History of significant head trauma ( causing loss of consciousness more than 5 minutes or neurological or cognitive sequels)
Liver, kidney, cerebrovascular or cardiovascular disease
Diabetes, metabolic syndrome
Cancer
Using antiepileptic (other than benzodiazepines for sleep) , antihypertensive, anticoagulant, anti-platelet drugs
Using inhibitors or stimulants of hepatic isoenzymes that metabolize melatonin or olanzapine (e.g. omeprazole. rifampin, fluvoxamine, ciprofloxacin, carbamazepine, modafinil)
Delirium
Need for administration of other antipsychotics
Substance abuse
Clareo Health | Melatonin for Prevention of Metabolic Side Effects of Olanzapine
