Weight Loss With Exenatide Treatment

Exclusion Criteria

• •Type 1 or type 2 diabetes mellitus diagnosed according to American Diabetes Association criteria
• •Unstable heart disease as evidenced by ongoing angina
• •Congestive heart failure
• •Uncontrolled hypertension (BP greater than 170/100 mmHg on or off antihypertensive medication)
• •Uncontrolled dyslipidemia (LDL greater than 200 or TG greater than 400 on or off lipid lowering medication)
• •Tobacco, marijuana, cocaine, or intravenous drug use
• •Shift workers (night shift or alternating day/night shifts)
• •Gastroparesis
• •Inflammatory bowel disease or irritable bowel syndrome
• •Malignancy treated with chemotherapy within the past 3 years
• •History of pancreatitis
• •Depression requiring hospitalization or diagnosis of psychosis
• •Renal insufficiency (eGFR less than 50)
• •Transaminases greater than 2 times above the normal range
• •Pregnancy within 6 months of the screening visit
• •Lactation
• •Failure to use medically approved contraceptive methods (monophasic oral contraception, intra uterine device, surgical sterilization or 2 combined barrier methods)
• •History of an eating disorder (anorexia, bulimia or laxative abuse)
• •Treatment with FDA-approved or over-the-counter weight loss medication within 6 months, with the exception of Xenical if there was no weight loss
• •History of gastric bypass surgery or gastric stapling
• •Biochemical evidence of hyper or hypothyroidism, or new diagnosis of hypo or hyperthyroidism within 3 months of screening visit
• •Previous treatment with exenatide
• •Discretion of the PI