Weight Loss With Exenatide Treatment

Primary Outcomes The primary objectives of this study is: \- To investigate possible mechanisms and patterns of weight loss with exenatide treatment, especially among individuals who have robust early weight loss (greater than 5% weight loss in 12 weeks) with exenatide. Secondary Outcomes Our secondary objective is to identify metabolic characteristics that predict robust response to exenatide treatment. Outcome measurements: * Weight * Body composition * Resting energy expenditure (REE) * Mixed meal test * Thermic effect of food * Serum metabolic parameters * Hunger/Nausea/Satiety visual analog scales (VAS) * Physical activity monitoring Study Population The study population will be generally healthy, non-diabetic women age 18-70 years with BMI 28-48 kg/m\^2.