Histology of Functional Density in Premenopausal Breast

Inclusion Criteria

• •Ages 40 - 55 years
• •Considered premenopausal or peri-menopausal
• •Screening mammogram performed at Mayo Clinic Rochester within one year prior to the current MBI study which demonstrates
• •Negative/benign assessment (BIRADS category 1-2) or Additional imaging recommended (BIRADS category 0), where the subsequent diagnostic workup results in a final negative/benign assessment (BIRADS category 1-2).
• •No proliferative benign lesions (e.g. fibroadenomas) identified
• •Heterogeneously dense or extremely dense parenchyma (BIRADs density category 3 or 4)
• •MBI performed less than 3 days prior to biopsy demonstrating either marked FD or photopenic FD in an area of mammographically dense tissue amenable to biopsy.
• •No use of exogenous hormonal drugs (e.g. hormonal contraceptives or sex steroid hormones) within six months prior to study biopsy
• •Negative pregnancy test or surgically sterilized (for patients in whom a study MBI will be performed)