Lead Sponsor

Michigan State University

Age

49 - 80 years

Sex

ALL

Healthy Volunteers

No

•postbronchodilator FEV1/FVC \<0.7 and FEV1 \<80% predicted \[FEV1 =volume that has been exhaled at the end of the first second of forced expiration\] and FVC volume of air that can be forcibly blown out after full inspiration\]
•history of smoking \>20 pack-years
•stable condition at inclusion with no infection or exacerbation for at least two months
•optimal medical therapy for at least eight weeks with no change

•history of active pulmonary disease such as asthma
•positive bronchodilator test
•treatment with N-acetylcysteine
•previous diagnosis of hypertension or current anti-hypertensive treatment
•known unstable or moderate to severe heart disease (arrhythmia, ischemic heart disease, or cardiomyopathy)
•previous diagnosis of chronic illness such as diabetes, renal failure, hypercholesterolemia, hepatic cirrhosis, cancer, rheumatoid arthritis or any other systemic inflammatory disease
•neuromuscular or disabling cognitive problems
•engagement in any exercise-training program during the past three months
•substance abuse in the preceding six months

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