Crizotinib and Ganetespib (STA-9090) in ALK Positive Lung Cancers

Exclusion Criteria

• •Prior crizotinib therapy
• •Inadequate recovery from any toxicity related to prior treatment (to Grade 1 or baseline).
• •Inadequate hematologic function defined as:
• •* Absolute neutrophil count (ANC) \< 1,000 cells/mm³.
• •* Platelet count \< 75,000/mm³
• •* Hemoglobin \< 9.0g/dL.
• •Inadequate hepatic function defined by:
• •AST and/or ALT \> 3x upper limited of normal (ULN).
• •Total bilirubin \> 2x ULN.
• •Alkaline phosphatase \> 3x ULN.
• •Patients with hepatic metastases may have ALT/AST ≤ 5x ULN.
• •Patients with hepatic and/or bone metastases may have an AP ≤ 5x ULN.
• •Inadequate renal function defined by serum creatinine \> 2x ULN Uncontrolled systemic fungal, bacterial, viral or other infection (defined as exhibiting ongoing signs/symptoms related to infection without improvement, despite appropriate anti-infective medications or other treatment).
• •Patients with clinically active brain metastasis (requiring therapy with steroids or radiation therapy). Patients with clinically stable brain metastases (previously treated or untreated) for two weeks are eligible.
• •Significant cardiac disease (e.g. New York Heart Association (NYHA) Class 3 or 4; myocardial infarction within the past 6 months; unstable angina; coronary angioplasty or coronary artery bypass graft (CABG) within the past 6 months; or uncontrolled atrial or ventricular cardiac arrhythmias).
• •Previously or current malignancies at other sites within the last 2 years, with the exception of adequately treated in situ carcinoma of the cervix, basal or squamous cell carcinoma of the skin, or prostate cancer that does not require active treatment per National Comprehensive Cancer Network (NCCN) guidelines.
• •Women who are pregnant or lactating
• •Use of drugs or food that are known potent CYP3A4 inhibitors (see Appendix C)
• •Use of drugs that are known potent CYP3A4 inducers (see Appendix D)
• •Any other condition that, in the opinion of the Investigator, may compromise the safety, compliance of the patient, or would preclude the patient from successful completion of the study.