Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Massachusetts, Worcester
With
National Institutes of Health (NIH)
The specific aims include:
Primary aims:
1. Examine the efficacy of salsalate (3g/day) in improving positive and negative symptoms as measured by the Positive and Negative Syndrome Scale (PANSS) and the Scale for Assessment of Negative Symptoms (SANS).
2. Examine the efficacy of salsalate in improving cognition as measured by the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) composite score.
Secondary aims:
1\. Examine salsalate's effects on inflammatory markers such as high sensitivity C-reactive protein (hs-CRP), TNF-α and IL-6.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18-65 years;
Diagnosis of schizophrenia or schizoaffective disorder;
Stable dose of the current antipsychotic drug for at least one month;
Well established compliance with outpatient treatment per treating clinician's judgment;
Able to complete the cognitive assessment battery (must be English speaking);
Female subjects will be eligible to participate in the study if they are of non-childbearing potential or of child-bearing potential and willing to practice appropriate birth control methods during the study.
You may not be if
Inability to provide informed consent;
Current substance abuse;
Psychiatrically unstable per treating clinician's judgment;
Significant medical illnesses including uncontrolled hypertension, diabetes, seizure disorder, severe cardiovascular, cerebrovascular, pulmonary, or thyroid diseases;
Currently on immunosuppressant medication including oral steroids;
Use of anti-coagulants (heparin, LMWH, warfarin, cilostazol, clopidogrel, dabigatran);
History of chronic infection (including, HIV and hepatitis), malignancy, organ transplantation, blood dyscrasia, central nervous system demyelinating disorder, and any other known autoimmune or inflammatory condition;
Experienced asthma, urticaria or allergic type reaction after taking aspirin, salsalate, or other NSAIDS;
