BMD T-score of ≤ -3.50 at the total hip or femoral neck

History of hip fracture

Any severe or more than 2 moderate vertebral fractures, as assessed by the central imaging based on lateral spine x-rays

Use of agents affecting bone metabolism

History of metabolic or bone disease (except osteoporosis)

Vitamin D insufficiency (vitamin D repletion and rescreening is permitted)

Current hyper- or hypocalcemia

Current, uncontrolled hyper- or hypothyroidism

Current, uncontrolled hyper- or hypoparathyroidism

Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis