Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Maastricht University Medical Center
Age
Any age
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Patients with AD:
Informed consent before participation in the study
Received standard diagnostic procedure according to the Parelsnoer Initiative procedure
Diagnosed with dementia of the Alzheimer's type
Clinical dementia rating (CDR) of 1, which means a mild to moderate stage of dementia
MMSE ≥ 20 and patients are mentally competent (in general, individuals with an MMSE ≥ 18 are considered mentally competent)
Patients with prodromal AD:
Informed consent before participation in the study
Received standard diagnostic procedure according to the Parelsnoer Initiative procedure
Diagnosis of prodromal dementia according to the Dubois criteria (16)
CDR of 0.5, which suggests a very mild stage of dementia
Memory impairment defined as Delayed Recall on Verbal Learning Test (15 WLT) \< 1.5 SD
MMSE ≥ 20 and patients are mentally competent.
Medial temporal lobe atrophy scale MTA ≥ 1 (17) OR abnormal levels of Aß42, t-tau or p-tau
Healthy participants:
Informed consent before participation in the study
No Diagnosis of dementia, prodromal dementia, or mild cognitive impairment.
MMSE ≥ 26
No substantial memory complaints (according to participant)
Age, gender and education is matched to the patient groups.
You may not be if
Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR \< 30 mL/min.
Major vascular disorders (e.g. stroke, heart disease)
Psychiatric or neurological disorders: Major depression (\< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (\< 12 mnd); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's disease; MS; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Meniere's disease; and brain infections.
Structural abnormalities of the brain
Cognitive impairment due to alcohol/drug abuse
Absence of reliable informant (for patient groups)
