Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.

Exclusion Criteria

• •Lean body weight \> 100 kg
• •Use of oral medications typically prescribed to raise low serum bicarbonate levels (i.e. sodium bicarbonate, sodium citrate, potassium citrate).
• •Serum potassium \< 3.5 meq/L at enrollment visit
• •Use of 5 or more antihypertensive agents, regardless of the indications of each agent
• •Systolic blood pressure \> 140 mmHg or diastolic blood pressure \> 90 mmHg at the enrollment or baseline visit
• •Diagnosis of congestive heart failure with current, active Class III or IV New York Heart Association symptoms.
• •Significant fluid overload such that it is unsafe in the opinion of the PI for the patient to participate in the trial
• •chronic gastrointestinal disorder or any other factors judged to be likely to limit adherence to interventions (i.e. alcoholism, a history of missing clinic visits)
• •Chronic immunosuppressive therapy for transplanted organs or other indications
• •Individuals who are currently a member of a vulnerable population (I.e. incarcerated, pregnant).
• •11.Currently participating in another interventional research study