Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Baker Heart and Diabetes Institute
With
The Alfred
Monash Medical Centre
Ballarat Health Services
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Aged 18-70 years.
Capable of understanding and willing to provide signed and dated written, voluntary informed consent in advance of any protocol-specific procedures.
MDD or MDD with melancholia according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Patients with comorbid panic or anxiety disorders will be included if MDD is the primary diagnosis.
Hamilton Depression (HAM D) \> 18.
Beck Depression Inventory (BDI-II) \> 18.
You may not be if
Aged \< 18 or \> 70 years.
Current antidepressant treatment.
Previous failed response to SSRI treatment at the maximum tolerated dose for at least 4 weeks.
Known or suspected hypersensitivity to the prescribed antidepressant or any of its ingredients.
Current high suicide risk.
Comorbid panic or anxiety disorders as the primary diagnosis.
Pre-existing and/or current diagnosed heart disease.
Comorbid medical conditions including type 1 diabetes, medicated hypertension, epilepsy, bleeding disorders, alcohol/drug dependence, infectious blood diseases, psychotic disorders, personality disorders, eating disorders, mental retardation, dementia (ie, Mini Mental State Examination \[MMSE\] \< 23), or gastrointestinal illness or previous bariatric (weight loss) surgery that may impair antidepressant absorption.
Clinically significant abnormalities on examination or laboratory testing and clinically significant medical conditions not listed above that are serious and/or unstable.
Pregnant or breastfeeding women.
Women of childbearing potential (WOCP) who are not using medically accepted contraception (ie, intrauterine devices \[IUDs\], hormonal contraceptives \[oral, depot, patch or injectable\], and double barrier methods such as condoms or diaphragms with spermicidal gel or foam). Women who are postmenopausal (amenorrhea for at least 12 consecutive months) or surgically sterile are not considered to be WOCP.
Clareo Health | Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
