Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Definitions Luminal A: tumors ER + PR + HER2 Negative and Ki67 \<14% Luminal B: tumors ER +/-, PR +/-, HER2 negative and Ki67 \>15% Complete pathologic response is defined as the abscence of malignant cells in breast tissue and lymph nodes. The presence of DCIS is considered as pCR
Age
18–70
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Women older than 18 years old and younger than 70 years old
* Invasive breast cancer confirmed by core biopsy, any histology
* Tumor ≥2 cm and/or lymph node positive (proven by FNA)(T2-4b, N0-3, M0)
* Must have ER/PR positive and HER2 negative
* Must have full staging and extent disease and clinically and radiographically tumor measure
* Without previous treatment for breast cancer (including surgery, hormonotherapy or chemotherapy)
Normal liver, kidney and blood tests
Performance Status ECOG 0-2 o Karnofsky ≥70%
Fasten glucose levels \<125 mg/dl
Signed consent
You may not be if
Previous use of metformin for any indication
Presence of Diabetes Mellitus
Clareo Health | Metformin Plus Neoadjuvant Chemotherapy in Breast Cancer
