Drug Interaction With Genes in Parkinson's Disease

Title : Drug interaction with genes in Parkinson Disease Objective: To identify genes associated to disease and treatment complication and response. Number of subjects: 500 Study duration : 6 years Design: Prospective cohort with biological collection Primary objective: Identification of genes which polymorphism or haplotype is associated with a complication of Parkinson disease, directly or with the interaction of treatment. Secondary objectives: * Prevalence and incidence of disease or treatment complications * Clinical risk factor for disease or treatment complications * Biomarkers of disease progression, disease or treatment complications