Pre-Release VIVITROL for Opioid Dependent Inmates

Exclusion Criteria

• •1. Current drug or alcohol dependence requiring long term residential treatment that would interfere with outpatient study participation. Dependence on substances that commonly co-occur with opioid dependence (e.g. cocaine, cannabis, alcohol) that do not rise to this level of severity will not be exclusionary in order to achieve a maximally representative sample.
• •2. Liver failure and/or liver function test levels greater than three times normal.
• •3. Pregnancy, lactation, or failure to use adequate contraceptive methods;
• •4. Active medical illness that might make participation hazardous, e.g. untreated hypertension, hepatitis with AST or ALT \> 3 times upper limit of normal, unstable diabetes or heart disease. Adequately treated medical conditions are acceptable.
• •5. Untreated psychiatric disorder that might make participation hazardous, e.g. untreated psychosis, bipolar disorder with mania, significant suicide risk. Adequately treated psychiatric disorders and appropriate psychotropic medications would be allowed.
• •6. History of allergic reaction to naltrexone;
• •7. Current chronic pain diagnosis for which opioids are required for pain relief.
• •8. Obesity (BMI of 40 or greater) to reduce the likelihood of injection site reaction.
• •9. Known intolerance and/or hypersensitivity to naltrexone, carboxymethylcellulose, or polylactide-co-polymers (PLG) or any other components of the diluents.