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Keep this study
Lead
Roswell Park Cancer Institute
PRIMARY OBJECTIVES:
I. To determine the feasibility of a mechanical stimulation regimen in hematopoietic cell transplant (HCT) patients.
SECONDARY OBJECTIVES:
I. To evaluate the data collection tools to prepare for a larger phase II trial.
OUTLINE:
Patients undergo mechanical stimulation over 20 minutes once daily (QD) beginning on date of hospital admission and continuing through day 100 post-HCT, except for day 0 (date of transplant).
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Meet eligibility criteria for first allogeneic HCT, and are scheduled to undergo allogeneic HCT
Pre-transplant Karnofsky Performance Status (KPS) \>= 70
Patient or legal representative must understand the investigational nature of this study and sign an Institutional Review Board approved written informed consent form prior to receiving any study related procedure
You may not be if
Any prior allogeneic HCT
Pre-transplant weight \>= 280 lbs
Body mass index (BMI) \< l8kg/m\^2
Human leukocyte antigen (HLA)-mismatched HCT
Cord blood transplant
Osteopenia or osteoporosis (T-score =\< -1.0)
Multiple myeloma diagnosis
Any prior history of a central nervous system (CNS) hemorrhage
Currently treated with a therapeutic dose of anti-coagulation for a recent pulmonary embolism or deep vein thrombosis
Current or previous bisphosphonate use
Prior history of non-traumatic fracture
Any screws, pins, rods, or other metal objects in the body
Total joint replacement
History of kidney stones or gall stones
Any artificial limbs
Pregnant or nursing female patients
Unwilling or unable to follow protocol requirements
Any condition which in the Investigator's opinion deems the patient an unsuitable candidate to receive study intervention
Clareo Health | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant
