Perindopril Amlodipine for the Treatment of Hypertension

Exclusion Criteria

• •Night shift workers whose work hours include midnight to 4:00 a.m.
• •Secondary hypertension
• •An arm size that precludes the use of the digital blood pressure monitor cuff (arm size \> 42 cm)
• •Renal dysfunction, severe renal impairment, bilateral renal artery stenosis, renal artery stenosis in a solitary kidney, subjects with only 1 kidney, or post-renal transplant subjects
• •Female subjects who are pregnant, planning to become pregnant
• •History of malignancy within 5 years
• •Primary aldosteronism
• •Heart failure (NYHA functional class 3-4), hypertrophic obstructive cardiomyopathy, or hemodynamically relevant stenosis of the aortic or mitral valve
• •Significant cardiac arrhythmias, MI, stroke, CABG, PTCA, unstable angina
• •Known hypersensitivity to any component of the study drugs