Long-Term Vesicular Monoamine Transporter II Imaging and Clinical Assessment of Parkinson's Disease Progression

Exclusion Criteria

• •1. Significant recent (within 6 months) history of neurological (including stroke and brain trauma) or psychiatric disorder.
• •2. Alcohol or substance abuse.
• •3. History or presence of QTc prolongation. (\>500msec)
• •4. History of intracranial operation, including thalamotomy, pallidotomy, and/or deep brain stimulation.
• •5. Unable to stay still in the MRI or PET scanner for 30 minutes.
• •6. Pregnancy and breast feeding.
• •7. Hepatic dysfunction with liver function test (alanine aminotransferase \[ALT\] and aspartate aminotransferase \[AST\]) of \> 3x the upper limit of normal