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Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD) | Clinical Trials | Clareo Health

TERMINATEDNA

Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)

Effect of Prophylactic, Perioperative Propranolol on Peri- and Postoperative Complications in Patients With Post Traumatic Stress Disorder

NCT01555554•University of California, San Francisco

View on ClinicalTrials.gov

Summary

Understanding what treatments may facilitate perioperative care of Veterans with posttraumatic stress disorder (PTSD) is of great importance to the U.S. health care system. Patients with PTSD are characterized by elevated central nervous system catecholamine concentrations and exaggerated and prolonged adrenergic responses to stress stimuli. At present, there are no data on the effects of perioperative beta blocker therapy in patients with PTSD, despite the rising significance of PTSD in Veteran populations. This prospective, double-blind study proposes to randomize 150 Veterans with PTSD scheduled for orthopedic, thoracic or vascular surgery at the San Francisco VA Medical Center to either a 14-day course of propranolol or placebo. This study will then follow these Veterans for a one-year period to evaluate the effects of the intervention on Veterans' surgical outcomes. The investigators hypothesize that patients with PTSD randomized to the propranolol group will demonstrate a reduced incidence of perioperative and postoperative morbidity and mortality.

Eligibility

Age

40 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Subjects scheduled for any surgical procedure under general anesthesia or combined general-regional anesthesia, with the exception of open-heart or intracranial surgery. Regional anesthesia includes: 1) Epidural anesthesia, 2) Sub-arachnoid block (spinal), or 3)any regional nerve block
•2. Anticipated postoperative hospital admission (defined as at least one overnight hospital stay)

Exclusion Criteria

•Veterans will be excluded if:
•1. They are on beta blocker therapy at the time of the preoperative baseline assessment
•2. They report sensitivity or allergies to propranolol, or a history of PTSD exacerbation with prior propranolol therapy
•3. Veterans who fulfill the AHA/ACC level I recommendation criteria for perioperative beta blocker therapy (e.g., metoprolol, atenolol) and should not be randomized to placebo group
•4. Medical exclusions criteria: high grade heart block without pacemaker (all patients with 2nd and 3rd degree heart block), marked resting bradycardia (heart rate ≤ 55 beats per minute), blood pressure \< 100 mmHg, uncompensated congested heart failure, severe hyperactive airway disease, and Raynaud's disease
•5. Pregnancy
•6. Current use of medication that may involve potentially dangerous interaction with propranolol
•7. Circumstances that, in the opinion of the principal investigator, would preclude participation in a study of this type (e.g. medical concerns or difficulty in long-term followup).
•8. Open-heart surgery and intracranial surgery

Locations (1)

San Francisco VA Medical Center

San Francisco, California, United States

Key Dates

Start Date

May 1, 2012

Primary Completion Date

June 1, 2018

Completion Date

June 1, 2019

Last Updated

July 26, 2021

Enrollment

ACTUAL participants

Conditions

Post-traumatic Stress Disorder

Interventions

Propranolol Hydrochloride

DRUG

Placebo

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 26, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)

Inclusion Criteria

Exclusion Criteria

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