Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Subjects with a diagnosis of RA
Subjects who have active RA at the time of screening
Subjects who haven't used any antirheumatic drugs or have used antirheumatic drugs for more than 3 months at the time of screening
Written informed consent

Subjects with serious cardiovascular, renal, hematologic or endocrine diseases
Pregnant or lactating women
ALT\>1.5×ULN, AST\>1.5×ULN, Cr\>135umol/L
WBC\<4×109/L，HGB\<85g/L，PLT\<100×109/L
Subjects with uncontrolled infection
Patients with active gastrointestinal diseases (such as gastric ulcer, etc.)
Allergic to any of the study drugs
History of alcoholism
Subjects receiving live vaccines within 3 months prior to study entry
Subjects participating in other clinical study within 3 months prior to study entry

A Study of Iguratimod in Patients With Active Rheumatoid Arthritis